Loop diuretics

 

Drugs acting onthe loop of Henle prevent Na+ ion reabsorption by inhibition of the Na+ K+ ATpase system that actively transports solute out of the loop into the medullary interstitium, thereby creating a hypertonic environment in the interstitium. They are called the  loop diuretics and they include frusemide, piretanide, torasemide, and ethacrynic acid.

 

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