Chronic myelogenous leukemia Chronic myelogenous leukemia

Chronic myelogenous leukemia

Tumor of white cells affecting the granulocyte series and with t (9;22) Philadelphia chromosome

Chronic myeloid leukemia (CML) is cancer of myeloid series of the blood corpuscles. It affects the  granulocyte series and with t (9;22) Philadelphia chromosome which is a result ftranslocation between the long arms of chromosome 9 and 22. The translocation chromosome then contains two genes placed together which are BCR (breakpoint cluster region) on chromosome 22 and ABL (Ableson leukemia virus) on chromosome 9, a proto-oncogene. This leads to a hybrid gene called BCR-ABL which then encodes for a protein that has tyrosine kinase activity that, ipso facto, becomes engulfed in signal transduction (a function of tyrosine kinases), leading to proliferation and new growth which means cancer.




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