Cirrhosis

This is fibrosis of the liver which is due to deposition of interstitial collagen type I and III. This leads to disruption of hepatic architecture and the architecture of vascular channels in the liver. Fibrosis comes from myofibroblasts existing in the liver while stellate cells produce interstitial collagen. Cirrhosis may be caused by post viral hepatitis, biliary disease, alcoholic liver disease, Wilson's disease and α1 antitrypsin deficiency.

Cirrhosis Normal liver tissue
 

 

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