Urticaria pigmentosa

 

Urticaria is a form of skin condition in which mast cells degranulate. In urticaria pigmentosa, the mast cells actually proliferate to form a mastocytosis. They release histamine on pressure causing a wheal formation or even dermographia. It is due to a point mutation on c-KIT proto-oncogene which activates KIT tyrosine kinase responsible for mast cell growth and differentiation. One which affects the infant is called infantile urticaria pigmentosa.

 

 

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