Rheumatic fever

 

This is a disease of children between the ages of 5-15 years after sore throat caused by group A streptococcal infection. The antibodies against this streptococcus cross react with cardiac antigens thereby causing antigen-antibody reaction to cardiac proteins. It is diagnosed by two major criteria

  • Minor criteria involves fever, leucocytosis and pain in joints.

  • Major or Jones criteria - in this category two of the five must be present.

    • Erythrema marginatum

    • Syndenham chorea

    • Carditis which may cause valvular problems in all valves of the body but mostly mitral valve

    • Subcutaneous nodules

    • Large joint arthropathy which are migratory.

    Aschoff bodies in the myocardium is diagnostic with formation of MacCallum plaques

 

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