Pemphigus

Autoimmune disease of skin which occurs in adults from ages 30-60 years, (with exception of an entity sometimes called pemphigus neonatorum). Antibodies are produced against desmoglein 3, which is found in desmosomes of intercellular junctions in keratocytes which then release plasminogen activator. There are four clinical types

  • Pemphigus vulgaris: found mainly in scalp, face, trunk and pressure points

  • Pemphigus vegetans: found mainly in flexor lines

  • Pemphigus foliaceus: distributed on face, upper trunk and scalp

  • Pemphigus erythematosus found in malar region


Bullous pemphigus

 

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