LEPROSY (Hansen's disease)

     

Symptoms: Wrist drop; foot drop; loss of hand and foot functions; skin rash.
Special signs: Macules, papules; nodules; neurological deficits- e.g. ulnar palsy (claw hand deformity) with wrist drop; foot drop; loss of fingers and toes. Curvature of thoracic spine laterally and anteroposteriorly.
Special investigations: PCR DNA yields very many false negative results; antiphenolic glycolipid (anti-PGL-1) for M leprae is also not very diagnostic. Diagnosis depends mostly on clinical presentation.

SHORT DESCRIPTION:
Disease is caused by
Mycobacterium leprae. Its clinical features run a spectrum from polar tuberculoid (TT) through borderline tuberculoid (BT) to mid-borderline (BB), to border line lepromatous (BL) and finally polar lepromatous leprosy.

 

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