Menopause

 

This is the situation in which the ovary has burnt itself out. During reproductive life the ovary would have 400 primordial follicles which would mature and ovulate and also produce estrogen in response to the production of pituitary gonadotropins- LH and FSH. As the number of follicles dwindle to zero the amount of estrogen produced will also go down to zero and would no longer be able to inhibit the production of the pituitary gonadotropins in the well known negative feedback or pituitary function. Therefore the pituitary gonadotropin increases astronomically while the production of estrogen reaches zero at menopause. This loss of estrogen causes the following

 

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Irritability

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Fatigue

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Anxiety

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Decrease calcification of bones

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Decrease strength in muscles

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Dyspnea

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Hot flushes

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Psychotic state in some cases

 

The so called perimenopausal syndrome when severe is a spectrum of the progesterone deficiency syndromes extending from premenstrual syndrome, through luteal phase defect to preeclampsia-eclampsia in perimenopausal syndrome.

 

                                           

 

 

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