Synthesis of vaccines

Vaccines can be produced using recombinant DNA technology. A portion of an infective agent can be obtained by synthesing its gene. The synthetic gene is then available to produce the antigen which then stimulates the antibody production. Sometimes the antigen may work as receptor to mop up infectious agents. In this case the antigen may be obtained directly form the human tissue receptor rather than infectious agent. Example is CD4+ receptors found in T lymphocytes to which HIV particles attach. Method have been adopted in which CD4+ receptors are produced in large amounts through recombinant DNA techniques  and injected into HIV infected patients, so that free CD4+ receptors are attached to the viral particles and then mop them up. The method presents how useful recombinant DNA can be in providing strategies for drug design and manufacture, but unfortunately, it has not been successful in HIV therapy

 

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