Physiology of ovulation


At ovulation, the LH surge activates the synthesis of progesterone and prostaglandins (PGs) in the membrana granulosa and corona radiata cells. The synthesis of PGE2, PGF2 and PGI2 and leukotrienes are believed to aid the process of ovulation. Prior to ovulation, the corona radiata cells become elongated and dissociated from each other There is a considerable dissociation of granulosa and cumulus oophorus cells. This is probably to allow for easier passage of the oocyte. The chemical substances that have been shown to aid ovulation includes plasminogen activator, collagenase and other proteolytic enzymes which aid the breakdown of collagen that helps to dissolve the tough tunica albuginea that covers the ovary, allowing for the escape of the ovum. Other hormones which aid the process of ovulation have also been implicated and the include oxytocin, locally produced gonadotropins and relaxin etc.

Ovulation and early cleavage video

Cross section through the ovary LP



Cell types



Gross anatomy
Lymphatic drainage
Organ integration
Clinical anatomy





Chemical Pathology

Anatomical Pathology







Folliculogenesis and ovulation




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