Histopharmacology of uterus

 

Oxytocics

The uterus is known for contractions of its myometrium and hence oxytocin which is a posterior pituitary hormone can be used in labor and also to accelerate or induce labor. It can also be used to accelerate labor. Oxytocin is the main drug which can perform this. Other oxytocics are as follows- dinoprostone. Some are administered by pessary such as misoprostol, gemeprost.

Prostaglandins are also used to cause or induce labor. These agents also have their action on cervical ripening or softening. They are as follows dinoprost (prostaglandin F2α), dinoprostone, gemeprost (prostaglandin E1 analogue), carboprost (prostaglandin F2α).

Ergometrine is another potent contractor of uterus. It is an α- adrenoceptor and dopamine receptor agonist.  Ergometrine produces faster contractions than the slow generalized contractions of oxytocin hence oxytocin is used to induce labor while ergometrine is used to prevent or treat post partum hemorrhage. Sometimes oxytocin and ergometrine are added together to form a potent oxytocic e.g. syntometrine.

Uterine relaxants

These reagents which prevent contraction of the uterus and are useful in preventing or stopping precipitate or spontaneous labor especially when it is not yet term.

They are mainly β2beta adrenoceptor agonists which inhibit premature labor. They may cause left ventricular failure. They include isoxsuprine, terbutaline, ritodrine, and salbutamol.

Contraceptives
 

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