Histopharmacology of striated muscle

 

Certain drugs act at the motor end or neuromuscular junction causing excitation or blockage. The drugs which cause blockage are often used in anesthesia to provide muscle relaxation and they include curare, suxamethonium, pancuronium, baclofen etc.

Intramuscular injection is one of the major ways of delivering drugs to the body  and this is favored because muscular tissue has considerable blood vessels that can quickly absorb such so that it is more rapid in reaching the blood stream than any other method of administration except of course intravenous injection. It is most often delivered to the gluteal region, but may also be injected into the deltoid or another robust skeletal muscle.

In myasthenia gravis, acetylcholine is produced for neurotransmission at the neuromuscular junction, but is useless since its receptors are broken down by autoantibodies and therefore cholinesterases eliminate acetylcholine molecules. Anticholinesterase is given to block the action of cholinesterase which breaks down acetylcholine. They include neostigmine or pyridostigmine.

 

 

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