Histopharmacology of psychotropic drugs

Drugs which act on the central nervous system and mood are called psychotropic drugs. They are as follows

Antidepressants: These are drugs which elevate the mood. They are

Tricyclics (imipramine, trimiparmine, lofepramine, amitriptyline), Dothiepin, riboxetine)

Selective serotonin reuptake inhibitors (SSRIs)-

Monoamine oxidase inhibitors (MAOIs)

Novel compounds, venlafaxine, nefazodone, mirtazapine, trazodone

Mechanisms- monoamine hypothesis. There is a deficiency of neurotransmitters norepinephrine and serotonin in depression which can be altered by antidepressants

Antipsychotics are used in psychotic conditions

Clozapine, olanzapine, quetiapine, risperidone, ziprasidone, amisulpride, zotepine, sertindole, penothiazines.

Classes of antipsychotics

  • Type 1- chlorpromazine, promazine

  • Type 2 thioridazine, pricyazine

  • Type 3- trifluoperazine, prochlorperazine, fluphenazine

  • Butyrophenones- haloperidol, benperidolm

  • Substituted benzamide- sulpiride

  • Thioxanthines- flupentixol, zuclopenthixol

Others pimozide, loxapine

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Electronic School of Medicine
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Central and peripheral nervous system pharmacology

 

 


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