Histopharmacology of penis

 

The main function which drugs can influence in the penis would be penile erection  which may have been blocked by anxiety and other sexual male dysfunctions (erectile dysfunctions-ED)

The drugs available are as follows

PDE5 inhibitor
This can be useful if it helps male erection.  Sidenafil (viagra) is a highly selective inhibitor of phosphodiesterase type 5. It inhibits the actions of isoenzymes 1, 2, 3, 4 and 5 of phosphodiesterases which terminate the action of cGMP in the penis.

Alprostadil
A stable form of prostaglandin E1 and also  a powerful and potent vasodilator. It is used for psychogenic and neurogenic ED and injected into the penis at its dorsolateral aspect of the proximal 1/3 of the penis.

Papaverine
It is alkaloid derived originally from opium but without any narcotic property.  It is injected into the corpora cavernosa shortly before intercourse. It may lead to priapism which is treatable.

Apomorphine
This is a dopamine antagonist and it is administered by subcutaneous injection.

Surgery:
Implantation by surgical means of semi rigid or inflatable penile prosthesis. It can be used for treatment when the case is refractory.

Vacuum constriction devices:
VCD draws blood into penis and then constricts in order to stop venous drainage. It causes erection and can be used to treat ED in male and female.

 

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Treatment of erectile dysfunction

 
Penis and scotum Dissected penis Parts of penis Perineum and scrotum from behind Scrotum from behind

Circumcised  penis Uncircumcised penis anatomy Structure of penis Fresh penis Variations

 

 

 

 

 

 

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