Ovary/contraception


 

Progesterone is a steroid hormone which was initially isolated form corpus lutea of sow. 20 mg of pure hormone was obtained from 600 kg of sow ovaries. This hormone seems to have considerable effect on the female reproductive system. It also seem paramount in its pure form for the treatment of many conditions of the female reproductive tract which can be collectively called progesterone deficiency syndromes. Ignorance is the cause of the many problems created by progestagens, which is that they lower the concentration of progesterone in blood thereby reducing the pure progesterone effects on the body such as its necessary simple and gentle effect on endometrium, which allows good and safe implantation as opposed to the accelerated effect of prostagens on the endometrium which leads to secretory exhaustion. Progestogens are  carcinogenic while progesterone is not.

Cholesterol-------Pregnenolone--------Progesterone---------17αhydroxyprogesteone------Androstenedione------Estrone---------Estradiol-17β

Progesterone comes in proprietary names such as ‘gemstone’ or ‘progestin’. The following are progestogens – hydroxyprogesterone hexaonate or caproate (Primolut Depot) , medroxyprogesterone acetate (Depot provera), megestrol acetate, chlormadione acetate and dydrogesterone.

Approved Name

Proprietary Name

Tablet Strength (mg)

Daily Dose (mg)

Medroxyprogesterone

‘Provera’

5

10-40

Dydrogesterone

‘Duphaston’

10

10-30

Ethisterone

‘Gestone Oral’

5,10, 25

25-100

Dimethisterone

‘Secrosteron’

5

15-40

Allyloestrenol

‘Gestanin’

5

10-20

Norethisterone

‘Primolut N’

5

5-30

Norethisterone acetate

‘Norluton A’

‘SH 420’

2.5

10

2.5-15

30-60

From JG Lewis Therapeutics, London: English Universities Press, 1972, p150.

Progesterone deficiency syndromes
Contraceptives

Ovulation drugs

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Clomifene an anti-estrogen is an ovulation inducer by blocking hypothalamic estrogen receptors which increases secretion of gonadotropin, leading to ovulation in 85% of women when given at 2-6 days of menstrual cycle in women.

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Hypothalamic hormone -gonadorelin - a gonadotropin release factor

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Anterior pituitary hormone such as FSH or chorionic gonadotropins

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 Bromocriptine which is used for hyperprolactinemia

 

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