Neuromuscular junction

This is the junction between the motor neuron and muscle which is its supplies. It is a muscarinic junction. Anticholinesterases allow acetylcholine to persist which then leads to fasciculation and the secondary depolarizing neuromuscular block.

Autoimmune disease causes disorder of neuromuscular transmission in myasthenia gravis.

Neuromuscular blocking drugs may be called muscle relaxants from the block depolarization at the junction thereby leading to muscle incontractility and relaxation. This is extremely desirable in surgery to relax muscles. The drugs which cause relaxation cause this by two mechanisms

  • Competition

  • Depolarization

Competitive blockers are as follows

cisatracurium, vecuronium, rocuronium, pncuronium, mivcurium, tubocurarine.

Depolarizing drugs include

suxamethonium

Others

baclofen,dantrolene

 

 
Neuromuscular junction

 

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Striated muscle explanatory video


Central and peripheral nervous system pharmacology

 
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