Histopharmacology of epithelium


Epithelium is tissue used for the process of absorption and hence help in the absorption of drugs. In the stomach the process of absorption is different from other parts of the gut such as the duodenum and small intestine. In the stomach it absorbs very quickly substances that have low dissociation constant in acidic gastric juice and also water, glucose and alcohol. Absorptive cell is most often a columnar cell in the intestine but other absorptive epithelia occurs as in the squamous epithelium of the skin which performs a modicum of absorption through the skin-e.g. embrocation and ointments, or on eye, lung (inhalation), anal canal, rectum (suppository) or vagina (pessary).

Others may be absorbed in rectum (suppository) in order to bypass the porto-caval circulation or irritation of the stomach. Yet others maybe absorbed in the mouth (sublingual-e.g. glyceryl trinitrate), or nasal mucosa (nasal spray).



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