Pathology of parathyroid gland


Parathyroid gland explanatory video

Multiple endocrine neoplasia I affects the parathyroid gland  and of course other glands such as those which are part of the endocrine APUD system causing neoplasia of the parenchyma. The gene for MEN-1 is on chromosome 11q13 and it is a tumor suppressor gene. Multiple endocrine neoplasia -2 (MEN-2 syndrome) is caused by mutations in tyrosine kinase receptor RET which is placed on chromosome 10q. MEN 1 and 2 lead to hyperparathyroidism.

There may also be non-MEN parathyroid adenoma. There is also a malignant transformation of the gland causing parathyroid carcinoma.

Links    Anatomy      Histology

Hyperparathyroidism syndromes

  • Primary hyperparathyrodism

    • MEN-1

    • MEN-2

    • Familial hypercalcuric hypercalcemia

  • Secondary hyperparathyroidism syndromes

    • Renal failure

Hypoparathyroidism

  • Surgical extirpation

  • Congenital absence of parathyroid gland

  • Idiopathic hypoparathyrodism

  • Autoimmune polyendocrine syndrome. This condition is caused by mutation in the autoimmune regulator gene (AIRE)



Parathyroid gland histology     Double click for full screen

 

     
 

 

 

 


Histology
Embryology
Gross Anatomy
Lymphatic drainage
Organ integration
Clinical anatomy

Quiz

Dissector

Physiology

Biochemistry

Pharmacology

Chemical Pathology

Anatomical Pathology

Imaging

Medicine

Surgery

 

Main Subject Course Links

eAnatomy eAnesthesia eBiochemistry eChemical pathology eCommunity Health
eDermatology eENT eGynecology eHematology eImaging
eMedicine eMedical microbiology eObstetrics eOphthalmology ePathology
ePediatrics ePharmacology ePhysiology ePsychiatry    eSurgery/eOrthopedics
eLab eOSCE eProcedures eInvestigations eSchool/Videopage
eOrgans eLocator Anatomy Museum eDissector eFractures/Dissect-it-yourself
All diseases eClerking eTreatment eDoctor ePatient

 

Electronic School of Medicine
Creator: Oluwole Ogunranti