Pathology of parathyroid gland
Multiple endocrine neoplasia I affects the parathyroid gland and of course other glands such as those which are part of the endocrine APUD system causing neoplasia of the parenchyma. The gene for MEN-1 is on chromosome 11q13 and it is a tumor suppressor gene. Multiple endocrine neoplasia -2 (MEN-2 syndrome) is caused by mutations in tyrosine kinase receptor RET which is placed on chromosome 10q. MEN 1 and 2 lead to hyperparathyroidism. There may also be non-MEN parathyroid adenoma. There is also a malignant transformation of the gland causing parathyroid carcinoma. Hyperparathyroidism syndromes
Hypoparathyroidism
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Parathyroid gland histology Double click for full screen
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Electronic School of Medicine
Creator: Oluwole Ogunranti