Blood film  

Red blood cell with basophilic stippling

The red cell has a central darkly stained area which may be mistaken for nucleus.  However the human red blood cells are non-nucleated.  The human red blood cell consists of prominent plasma membrane which has the capacity to change its form in relation to anatomical and physiological situations.  The membrane is semipermeable but it is impermeable to large molecules including hemoglobin, which the cells contain.  The membrane changes its shape in conditions of blood hyper or hypotonicity.  It also changes its shape in the process known as diapedisis which is a condition in which the red cell moves through capillary endothelial spaces into tissue fluid, and change shape to accommodate itself in the tight spaces in inflammatory conditions.  The red blood cell is devoid of Golgi apparatus and endoplasmic reticulum.

 

 

 

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