Histamine

 

It is found in a variety of paraneurons like the most cells and gastric ECL cell. It is also found in the pituitary gland (anterior). The histamine content of the brain is increased by the drugs tremorine and mescaline but decreased by reserpine. It does not seem to be a very important biogenic amine in behavioural modulation and in neurotransmission but is highly important in immune and allergic responses to the level of dopamine in the brain. Thus drugs that cause increase in dopamine secretion like amphetamines cause psychoses. Drugs that cause depletion of dopamine are utilized in antipsychotic therapy e.g. phenothiazines.

 

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