Gastrin Gastrin is produced by G-cells of the stomach and TG cells of the intestine, and in the pituitary gland. There are three molecular forms of gastrin which have been isolated.
a) G17 – contains 17 amino and residues
b) G-34 contains 34 amino acid residues. It is sometimes called big gastrin.
c) G-14 or minigastrin – contains 14
amino acid residues and is isolated in blood and tissue. G – 17 is the most
abundant and active of the three gastrins.
Three major factors increase the secretion of gastrin.
a) Luminal (peptides and amino acids, distension),
b) Neural (vagal discharge)
c) Blood-borne calcium and adrenalin
Also acid, secretion GIP, VIP, glucagons and calcitonin cause inhibition of gastrin release. But the neural mechanism of increased secretion of gut hormone have been challenged because they have never been demonstrated histologically. In the case of gastrin recent reports suggest that neuron, approach G and at a distance of 300m. Gastrin causes increased secretion of acid in the stomach.
Electronic School of Medicine
Creator: Oluwole Ogunranti