Gastrin Gastrin is produced by G-cells of the stomach and TG cells of the intestine, and in the pituitary gland. There are three molecular forms of gastrin which have been isolated.

a)         G17 contains 17 amino and residues

b)         G-34 contains 34 amino acid residues. It is sometimes called big gastrin.

c)         G-14 or minigastrin contains 14 amino acid residues and is isolated in blood and tissue. G 17 is the most abundant and active of the three gastrins.
Two other types of gastrin have been isolated in tissue fluid (Big big gastrin) both larger than G-34. It is not known whether they are biologically active.

Three major factors increase the secretion of gastrin.

            a)         Luminal (peptides and amino acids, distension),

            b)         Neural (vagal discharge)

            c)         Blood-borne calcium and adrenalin

Also acid, secretion GIP, VIP, glucagons and calcitonin cause inhibition of gastrin release. But the neural mechanism of increased secretion of gut hormone have been challenged because they have never been demonstrated histologically. In the case of gastrin recent reports suggest that neuron, approach G and at a distance of 300m. Gastrin causes increased secretion of acid in the stomach.





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