Large bronchus                                      Chart

                
Cell types: Ciliated, brush, basal, goblet cells
 

Differential diagnosis:
 All large holow organs (non-respiratory) are likely to be confused with trachea or bronchus but the main distinguishing feature will be the cartilage in the adventitia and the presence of pseudostratified columnar epithelium. Bronchus or bronchioles tend to be smaller, with smaller, cartilage, goblets cells and glands than trachea.

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Diagnostic Features:
a. Tissue is hollow and presents with  a large lumen which fills more than 1/1oth of low power field.
b. The epithelium is of pseudostratified variety and there is abundant cartilage of hyaline variety.
c. There is muscular tissue also in adventitia and prominent tracheal submucous glands.
d. Lung tissue is visible at the outermost part of adventitia. This distinguishes from trachea.
e. Goblet cells are many.

Draw your own section here and make your diagnosis by data base selection below

 

 

 

 

 

 

 

 

 

 

 

Database selection: Practical Tissue Gross

Level 1: Select  hollow since the large-bronchus is a hollow organ.
Level 2: Select large as opposed to small since lumen fills more than 1/10th of low power field for tissues of rat to man. This will select from database both cartilage and non cartilage containing tubes.
Level 3: Select cartilage. This will pick bronchi and trachea which are structures that have cartilage in their adventitia.
Level 4: Select lung since bronchus can be seen with sections of the lung. This picks out only bronchus and eliminates trachea.

Note the musculature of the adventitia and its cartilage. Note the goblet cells. The submucous glands and cartilage tissue and compare with trachea.

 

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