Duodenum                                      Chart

            
Cell types: Absorptive, paneth, goblet, mesothelial and enteroendocrine cells.
 

Differential diagnosis:
Other columnar epithelium of the rest of the gut tube can be distinguished from the duodenum by absence of low lying numerous villi. There are no pits in the duodenum but prominent submucous glands.

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Diagnostic Features:
a. Tissue is hollow (e.g.) esophagus and presents with a lumen which fills more than 1/10th of low power field.
b. There are numerous villi (much more in duodenum than other parts of gut) and they are low lying as opposed to tall villi in the ileum.
c. Simple columnar epithelium covers the surface and there are special glands in the submucosa called glands of Brunner. Also epithelial glands, the crypts of Lieberkuhn are present with plicae circulares.

Draw your own section here and make your diagnosis by data base selection below

 

 

 

 

 

 

 

 

 

 

 

Database selection: Practical Tissue Gross

Level 1: Select  hollow since the duodenum is a hollow organ.
Level 2: Select large as opposed to small since lumen fills more than 1/10th of low power field for tissues of rat to man. This will selects from database both cartilage and non cartilage containing tubes.
Level 3: Select no cartilage. This eliminates the trachea and other respiratory tract tubes and selects mainly digestive system organs.
Level 4: Select villi which picks up all structures in the gut which present with villi or villi-like structure and they include duodenum, ileum and jejunum. Small villi eliminates other structures and selects only duodenum.

Note the musculature of the muscularis externa. Can you identify the glands of Brunner, the crypts of Liberkuhn and the prominent goblet cells?

 

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