EC like cell




They are EC-like cells which are argyrophilic, enteroendocrine, APUD cells in the gut which contain histamine granules. It is proposed that they may be the source of antipernicious principle or the intrinsic factor. The cell is usually always closed and flattened without any apical process.

            ECL cell has been found to become hyperplastic after prolonged achlorhydria or hypochlorhydria caused by gastrecotomy, antacid therapy or as a consequence of pernicious anemia. Earlier investigators noted a relationship between increased gastrin levels and ECL cell hyperplasia suggesting that ECL proliferation is mainly due to high gastrin levels. ECL cells are involved in hyperacidity of peptic ulcer disease (PUD) and gastro-esophageal reflux disease (GORD). The main reason for the increase in gastrin levels by anti cholinergic drugs is not fully understood.





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