They are EC-like cells
cells in the gut which contain
granules. It is proposed that they may be the source of antipernicious
principle or the intrinsic factor. The cell is usually always closed
and flattened without any apical process.
ECL cell has
been found to become hyperplastic after prolonged achlorhydria or
hypochlorhydria caused by gastrecotomy, antacid therapy or as a
consequence of pernicious anemia. Earlier investigators noted a
relationship between increased
levels and ECL cell hyperplasia suggesting that ECL proliferation is
mainly due to high
levels. ECL cells are involved in hyperacidity of peptic ulcer disease
(PUD) and gastro-esophageal reflux disease (GORD). The main reason for the increase in
levels by anti cholinergic drugs is not fully understood.