Argentaffin-endocrine cell (respiratory tract)

 

  

 

Argentaffin cells of the bronchiolar epithelium are quite interesting from many respects. In the first place they possess the argentaffinic reaction (a reaction to silver substances in which reduced silver is deposited from ammoniated silver hydroxide solutions) and in the second, they have been recognized to be APUD cells and also paraneurons. By virtue of this recognition, they bear a close relationship with the argentaffin cells of the gastrointestinal tract and they are therefore endocrine in function. They have been called different names Kulkitschy is the most common in modern literature and three types have been identified to date called Pulmonary KI, KII and KIII cells.  They have also been identified to produce both ACTH and calcitonin and in view of this characteristic of peptide production, immunocytochemistry can be applied to demonstrate individual cells.

Roll over mouse to stain thyroid section with argentaffin reaction and note argyrophilic C cells

 

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